2,3-dihydro-1,4-benzodioxine-5-carboxylic acid
2,3-dihydro-1,4-benzodioxine-5-carboxylic acid
CAS: 4442-53-9
Molecular Formula: C9H8O4
2,3-dihydro-1,4-benzodioxine-5-carboxylic acid - Names and Identifiers
| Name | 2,3-dihydro-1,4-benzodioxine-5-carboxylic acid |
| Synonyms | AKOS BBS-00002750 5-CARBOXY-1,4-BENZODIOXANE 1,4-BENZODIOXAN-5-CARBOXYLIC ACID 1,4-BENZODIOXANE-5-CARBOXYLIC ACID 2,3-dihydro-1,4-benzodioxine-5-carboxylic acid 2,3-DIHYDRO-1,4-BENZODIOXINE-5-CARBOXYLIC ACID 2,3-DIHYDRO-BENZO[1,4]DIOXINE-5-CARBOXYLIC ACID 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid 2,3,4a,8a-tetrahydro-1,4-benzodioxin-5-carboxylic acid 7,10-dioxabicyclo[4.4.0]deca-1,3,5-triene-2-carboxylic acid |
| CAS | 4442-53-9 |
| EINECS | 224-670-0 |
| InChI | InChI=1/C9H8O4/c10-9(11)6-2-1-3-7-8(6)13-5-4-12-7/h1-3H,4-5H2,(H,10,11) |
| InChIKey | VCLSWKVAHAJSFL-UHFFFAOYSA-N |
2,3-dihydro-1,4-benzodioxine-5-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C9H8O4 |
| Molar Mass | 180.16 |
| Density | 1.376±0.06 g/cm3(Predicted) |
| Melting Point | 90-94°C(lit.) |
| Boling Point | 334.1±41.0 °C(Predicted) |
| Flash Point | 139.334°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Crystal |
| Color | Light yellow to Brown |
| pKa | 4.09±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.587 |
| MDL | MFCD00239415 |
| Physical and Chemical Properties | Off-white or white crystalline powder. Melting point 189-192 °c. |
2,3-dihydro-1,4-benzodioxine-5-carboxylic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S36/37/38 - |
| WGK Germany | 3 |
| HS Code | 29329900 |
| Hazard Note | Irritant |
2,3-dihydro-1,4-benzodioxine-5-carboxylic acid - Introduction
2,3-dihydro-1, acid is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 2,3-dihydro-1, acid is white crystal or crystalline powder.
-Solubility: It is soluble in some organic solvents, such as methanol, chloroform and dichloromethane. Insoluble in water.
Use:
-Chemical research: 2,3-dihydro-1, acrylic is widely used as an intermediate in organic synthesis.
-Pharmaceutical industry: Its derivatives can be used to synthesize certain drugs, such as anti-cancer drugs, antiviral drugs, etc.
Preparation Method:
There are usually two ways to synthesize 2,3-dihydro-1, acetyl:
-Through the cyclization reaction: The cyclization reaction can be carried out using appropriate chemical reagents under appropriate conditions, such as the reaction of acetyl chloride and methyl cycloacrolein to obtain 2,3-dihydro-1, pyridine.
-Through oxidation reaction: 2,3-dihydro -1,4-benzodioxane can be oxidized with an appropriate oxidizing agent, such as hydrogen peroxide or potassium permanganate, and then subjected to carboxylation reaction to obtain the target product.
Safety Information:
- 2,3-dihydro-1, acid has no risk to human health under normal circumstances, but as a chemical substance, the following safety measures should be paid attention:
-contact with the skin should be promptly rinse with plenty of water.
-Avoid inhaling dust and wear appropriate protective equipment such as gloves, glasses and masks.
-During the experiment or use, you should follow the correct operating specifications and ensure that you operate in a well-ventilated environment.
-should be stored in a dry, cool, ventilated place, away from fire and flammable substances.
-Before using any chemical, please check the safety technical manual or consult a professional to ensure safe operation.
Nature:
-Appearance: 2,3-dihydro-1, acid is white crystal or crystalline powder.
-Solubility: It is soluble in some organic solvents, such as methanol, chloroform and dichloromethane. Insoluble in water.
Use:
-Chemical research: 2,3-dihydro-1, acrylic is widely used as an intermediate in organic synthesis.
-Pharmaceutical industry: Its derivatives can be used to synthesize certain drugs, such as anti-cancer drugs, antiviral drugs, etc.
Preparation Method:
There are usually two ways to synthesize 2,3-dihydro-1, acetyl:
-Through the cyclization reaction: The cyclization reaction can be carried out using appropriate chemical reagents under appropriate conditions, such as the reaction of acetyl chloride and methyl cycloacrolein to obtain 2,3-dihydro-1, pyridine.
-Through oxidation reaction: 2,3-dihydro -1,4-benzodioxane can be oxidized with an appropriate oxidizing agent, such as hydrogen peroxide or potassium permanganate, and then subjected to carboxylation reaction to obtain the target product.
Safety Information:
- 2,3-dihydro-1, acid has no risk to human health under normal circumstances, but as a chemical substance, the following safety measures should be paid attention:
-contact with the skin should be promptly rinse with plenty of water.
-Avoid inhaling dust and wear appropriate protective equipment such as gloves, glasses and masks.
-During the experiment or use, you should follow the correct operating specifications and ensure that you operate in a well-ventilated environment.
-should be stored in a dry, cool, ventilated place, away from fire and flammable substances.
-Before using any chemical, please check the safety technical manual or consult a professional to ensure safe operation.
Last Update：2024-04-09 02:00:46
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